Proginova IVF: instructions for use

In the IVF protocol, a woman can get an appointment to receive Proginova. It is believed that this drug significantly increases the chances of a successful IVF.

We will tell in this material about why he is prescribed, how the remedy works, and how effective it is.

In vitro fertilization is a complex process, at each stage of which a woman needs additional hormonal support, which significantly increases the likelihood of successful completion of the protocol. Successful occurrence of a long-awaited pregnancy. “Proginova” is a hormonal drug that is included in the substitution therapy scheme. This means that identical to the natural estradiol contained in the drug, replaces the lack of its own estrogens in barren women.

Works "Proginova" as a means which suppresses the production of natural estradiol, and fully compensates for its level in the female body. So doctors can take control of the work of the ovaries at the preparatory stage of the IVF protocol. When doctors keep the hormonal level of the patient under their full control, the probability of spontaneous fluctuations of the hormonal level is excluded.

The drug is produced in France. Release form - dragee. Each dragee contains 2 mg of estradiol and a small amount of additional components like corn starch, lactose monohydrate and magnesium stearate. Drops are packed in blisters, each containing 21 pills.

Women can pay attention to the fact that on the shelves of pharmacies there is another drug - “Cyclo-Proginova”, but this means is different in composition and purpose. It contains not only estradiol, but also progesterone. In drug schemes of in vitro fertilization "Cyclo-Proginova" is used infrequently.

Outside of situations involving the planning of pregnancy with the use of reproductive assistive technologies, the tool is quite widely used in women who are entering a difficult climacteric period.

"Proginova" allows you to restore the deficiency of female sex hormones, which, due to the extinction of ovarian function, are not able to be produced in the required amount. Due to this, negative manifestations of menopause are reduced - “hot flashes” decrease, headaches, a woman becomes less irritable, less often complains of pain in muscles and joints. Increased heartbeat, sweating and poor sleep are a thing of the past.

In the ECO protocols, Proginova takes over the work of a woman's ovaries, who are preparing to collect eggs and replant fertilized oocytes in the future.

Despite the fact that the drug belongs to hormonal drugs, to which the attitude of the people is rather wary, there are clear positive side effects from taking it: the woman’s skin becomes more beautiful and dense, the amount of collagen in it increases,wrinkle formation and natural physiological aging are “delayed.”

The drug is prohibited to take women with vaginal bleeding of unknown origin. If the cause of discharge from the genital organs cannot be established, “Proginova” is not assigned.

Also, it is forbidden to prescribe the drug to women with:

• thromboembolism and arterial thrombosis;
• deep vein thrombosis;
• hormone-dependent tumors;
• neoplasms in the liver;
• some forms of diabetes.

Relative contraindications are many other conditions in which a woman while taking the drug "Proginova" will be observed more carefully and carefully. Endometriosis (even if it was previously a woman), hypertension, asthma, and epilepsy require special medical monitoring.

The use of the drug due to the purpose of his appointment. If the doctor recommends “Proginova” to increase the functional uterine endometrium, the drug is started on the 7th day of the menstrual stimulated cycle.

To support the endometrium, in order to increase the probability of successful implantation of embryos, the agent can be administered starting from the day of embryo replanting, after embryo transfer or earlier - immediately after follicle puncture.

And even with a full-term pregnancy, if a woman is re-wearing a fetus, the “Proginova” method is shown, which stimulates generic activity. As you can see, the range of use of funds is quite wide. In each case, the doctor prescribes a means of expediency, justification in a given dosage courses of different durations.

To stimulate the work of the ovaries before the stimulated cycle of IVF, the drug can be recommended both from the previous 25 cycle and 3 weeks before entering the stimulated cycle. In the process of taking dragee, women make ultrasound monitoring of the ovaries and measure the thickness of the endometrium, which is very important for the stimulated cycle.

In hormone replacement therapy (HRT), the most commonly used scheme is in which the drug is started up one week before the end of the previous cycle and continues continuously until the puncture of the follicles and after it until the fact of pregnancy is established. In some cases, the woman continues to drink jelly beans and being pregnant until 8-10 weeks of pregnancy.

In the combined scheme, they often take “Proginova” together with “Utrogestan” or “Duphaston”. Preparations of the combined regimen together cancel no sooner than the woman will form the placenta, which will take over the functions of the hormonal support for further gestation.

After the transfer in two weeks, a blood test for hCG is necessarily done, the results of which make a decision - if the pregnancy has occurred, the drug is prolonged, if not - the drug is withdrawn. Thus, the abolition of the drug during pregnancy after IVF occurs not immediately and very gradually, up to 10 weeks of pregnancy.

Tablets that are prescribed to stimulate controlled ovarian behavior when planning pregnancy with IVF can be taken without special reference to meals and time of day. The main thing is to try every day to take a hormonal remedy at about the same time. This will ensure an even hormonal background. Therefore, you need to choose a time to make it convenient every day.

A woman should not cancel the drug without permission, change the dosage - cancel and prescribe medication only for medical reasons. When the occurrence of side effects must be consulted. In some cases, dosage adjustment may be sufficient for better tolerability.

Women who start taking the drug in the IVF protocol scheme are concerned about the question, but how will a hormonal drug affect their well-being and overall health? The most common side effect of Proginova is a change in body weight (downward or downward). Most often, women in their reviews refer to the fact that they began to quickly add kilograms.

The second common complaint is a feeling of distention, bloating during the reception of dragees. Many feel depressed, because estrogens have a pronounced effect on the nervous system and mood.

Other side effects of the drug include:

• the occurrence of obsessive nausea, and sometimes vomiting;
• the appearance of an itchy allergic rash;
• changes in sexual desire (from increased libido to the complete absence of desire for sexual intimacy);
• acne;
• severe headaches and dizzy spells;
• swelling of the legs, arms, face;
• visual impairment;
• weakness and rapid heartbeat;
• stomach ache;
• bleeding from the genitals.

A long-term reception of "Proginova" without interruption increases the likelihood of developing cancer tumors.

The drug belongs to the group of hormonal steroid drugs, in pharmacies sold by prescription.

Tablets are stored for 5 years from the time of manufacture.

How else can you increase the chances of success of the IVF protocol, you will learn from the following video.